REVIEW
Introdução: entender o histórico da psicocirurgia é fundamental para contextualizar os avanços recentes na área e atualizar nossas percepções sobre o tema. Objetivo: mapear e narrar a abrangência e as características das pesquisas científicas conduzidas por autores filiados a instituições brasileiras sobre o tratamento neurocirúrgico do Transtorno Depressivo Refratário e fornecer evidencias que apoiem o processo de ensino e aprendizagem dessa temática. Método: realizou-se uma Revisão de Escopo a partir de um levantamento bibliográfico nas bases Pub Med, Lilacs, SciELO, BVS, Portal Capes e website de periódicos. Descreveu-se o desenho dos estudos, os procedimentos cirúrgicos utilizados e conclusões. Resultados: foram incluídas quarenta publicações, realizadas de 1944 a 2024. Em torno de 52,5% das publicações foram em fontes nacionais. As instituições com maior número foram a USP-SP (8), Hospital do Juqueri (7) e Universidade do Extremo Sul Catarinense (6), e as instituições estrangeiras: University of Texas (6), Massachussets General Hospital – Harvard Medical School (4), University of Toronto (4) e Toronto Western Hospital (3). Encontrou-se estudos que relatam leucotomias, lobotomias, cirurgias estereotáxicas ablativas com termocoagulação, radiocirurgia e estimulação cerebral profunda. Conclusão: ofereceu-se uma visão geral das evidências emergentes no campo da Psicocirurgia para o Transtorno Depressivo Refratário.
Introduction: Understanding the history of psychosurgery is essential to contextualize recent advances in the field and update our perceptions on the topic. Objective: To map and describe the scope and characteristics of scientific research conducted by authors affiliated with Brazilian institutions on the neurosurgical treatment of Refractory Depressive Disorder and provide evidence to support the teaching and learning process on this topic. Method: A scoping review was conducted based on a bibliographic survey of PubMed, Lilacs, SciELO, BVS, Portal Capes, and journal websites. The study designs, surgical procedures used, and conclusions were described. Results: Forty publications published between 1944 and 2024 were included. Approximately 52.5% of the publications were from national sources. The institutions with the largest number were USP-SP (8), Hospital do Juqueri (7), and Universidade do Extremo Sul Catarinense (6), and abroad institutions included the University of Texas (6), Massachusetts General Hospital – Harvard Medical School (4), University of Toronto (4), and Toronto Western Hospital (3). Studies reporting leukotomies, lobotomies, stereotactic ablative surgeries with thermocoagulation, radiosurgery, and deep brain stimulation were found. Conclusion: an overview of emerging evidence in the field of psychosurgery for refractory depressive disorder was provided.
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1Faculdade de Medicina – FAMED, Universidade Federal de Uberlândia – UFU, Uberlândia, MG, Brasil.
2Departamento de Cirurgia Esterotáxica, Hospital de Clínicas da Universidade Federal de Uberlândia – HC-UFU/EBSERH, Uberlândia, MG, Brasil.
3Laboratório de Anatomia Funcional aplicada à Clínica e Cirurgia, Faculdade de Medicina – FAMED, Universidade Federal de Uberlândia – UFU, Uberlândia, MG, Brasil.
Received Sept 16, 2025
Corrected Nov 5, 2025
Accepted Dec 10, 2025
