Lipomatous Meningioma: report of a rare variant

Resumo

O meningioma lipomatoso é uma variante histológica extremamente rara do meningioma, caracterizada por células com núcleos periféricos e citoplasma claro devido ao acúmulo intracelular de lipídios. O diagnóstico baseia-se em marcadores imuno-histoquímicos, incluindo o antígeno de membrana epitelial (EMA) e a proteína S-100. A apresentação clínica e o manejo dependem da localização e do tamanho do tumor, sendo cefaleias e convulsões os sintomas mais comuns. Este subtipo afeta predominantemente mulheres com mais de 55 anos. Dado o seu índice de recorrência de 17%, a ressecção total macroscópica é a abordagem cirúrgica preferida. Este estudo de caso descreve a intervenção cirúrgica bem-sucedida em uma paciente de 48 anos com meningioma lipomatoso, contribuindo para a compreensão e o manejo dessa rara neoplasia do sistema nervoso central.

Palavras-chave

Neoplasias intracranianas; Meningioma; Variante

Abstract

Lipomatous meningioma is an extremely rare histological variant of meningioma, characterized by cells with peripheral nuclei and clear cytoplasm due to intracellular lipid accumulation. Diagnosis relies on immunohistochemical markers, including epithelial membrane antigen (EMA) and S-100 protein. Clinical presentation and management depend on the tumor’s location and size, with headaches and seizures being among the most common symptoms. This subtype predominantly affects women over the age of 55. Given its 17% recurrence rate, gross total resection is the preferred surgical approach. This case study describes the successful surgical intervention in a 48-year-old patient with lipomatous meningioma, contributing to the understanding and management of this rare neoplasm of the Central Nervous System.

Keywords

Intracranial neoplasms; Meningioma; Variant

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