ORIGINAL

Endovascular Treatment of Middle Cerebral Artery Aneurysms

Tratamento Endovascular de Aneurismas de Artéria Cerebral Média

  • Leandro José Haas
  • Guilherme Wandall    Guilherme Wandall
  • Douglas Cipriano de Souza
  • Wesley Severino
  • Amanda Junges Derlam1
  • Eduarda Alves
  • Ana Boaventura
  • André Felipe Kroenke
  • Gabriela Scheidt
  • Camila Ceruti dos Santos
  Views: 18
  Downloads: 3

Resumo

Introdução: A artéria cerebral média (ACM) revela formações aneurismáticas, podendo se manifestar de forma única ou múltipla ao longo de seu leito, havendo fatores predisponentes para seu desenvolvimento e sítios prevalentes. Através da abordagem endovascular é possível realizar um tratamento mais delicado, assim como a ocorrência de complicações. Dessa forma, a triagem destes aneurismas na população alvo é relevante para a sobrevida destes pacientes. Objetivo: Analisar casos de pacientes com aneurisma de artéria cerebral média tratados por método endovascular em serviço de referência. Métodos: Estudo observacional retrospectivo com abordagem quantitativa de 368 pacientes com aneurismas de ACM submetidos a tratamento endovascular em serviço de neurocirurgia endovascular no período de 2005 a 2023. Resultados: O sexo feminino foi o mais acometido (73,91%), de meia idade (55,1 anos), com hipertensão arterial (74,18%). Prevaleceu o aneurisma sacular pequeno (94,29% / 83,97%) na bifurcação da ACM (79,89%), predominantemente não rotos (64,67%) correspondendo a escala de Fisher 1 e Grau 0 na escala de Hunt & Hess. A abordagem endovascular foi o procedimento de escolha em que a utilização de Coils prevaleceu (70,65%). Conclusão: Pacientes do sexo feminino, de meia idade, com hipertensão devem ser investigadas quanto a presença de doença aneurismática em ACM, uma vez que a probabilidade de não rotura é incerta, e a abordagem destas pacientes deve ter como foco o tratamento endovascular por ser uma conduta segura, com baixas taxas de insucesso, a fim da manutenção da vida destes.

Palavras-chave

Aneurisma intracraniano; ACM; Artéria cerebral média; Neurocirurgia; Procedimentos Endovasculares; Doença aneurismática

Abstract

Introduction: The middle cerebral artery (MCA) can develop aneurysmal formations, which may occur as single or multiple along its course, influenced by predisposing factors and prevalent sites. Endovascular approaches allow for more delicate treatments, though they also carry the risk of complications. Therefore, screening these aneurysms in target populations is crucial for patient survival. Objective: To analyze cases of patients with middle cerebral artery aneurysms treated using the endovascular method in a specialized center. Methods: A retrospective observational study with a quantitative approach, including 368 patients with MCA aneurysms treated with endovascular techniques in an endovascular neurosurgery center from 2005 to 2023. Results: The female gender was most affected (73.91%), with a mean age of 55.1 years, and a significant prevalence of hypertension (74.18%). Small saccular aneurysms (94.29% / 83.97%) were most common, predominantly located at the MCA bifurcation (79.89%) and mostly unruptured (64.67%), corresponding to Fisher Grade 1 and Hunt & Hess Grade 0. Endovascular intervention was the treatment of choice, with coil embolization being the predominant technique (70.65%). Conclusion: Female, middle-aged, hypertensive patients should be investigated for the presence of MCA aneurysmal disease, as the probability of rupture is uncertain. The treatment focus should be on endovascular procedures, which are safe and have low failure rates, ensuring better survival outcomes.

Keywords

Intracranial aneurysm; MCA; Middle cerebral artery; Neurosurgery; Endovascular Procedures; Aneurysmal disease

References

1. Liu J, Chen Y, Zhu D, et al. A nomogram to predict rupture risk of middle cerebral artery aneurysm. Neurol Sci. 2021;42(12):5289-96. https://doi.org/10.1007/s10072-021-05255-6. PMid:33860397.

2. Brasileira R, Fillus IC, Solana De Oliveira C, Conte T, Frederico C, Rodrigues A. Artigos de revisão análise dos aneurismas intracranianos operados no Hospital Policlínica Pato Branco-PR. Revista Brasileira de Neurologia e Psiquiatria. [Internet]. 2017 [Accessed: 6/1/2026];21(1): 51-9. Available from: http://www.revneuropsiq.com.br

3. Liang F, Yang Y, Luo L, et al. Endovascular treatment of complex middle cerebral artery aneurysms using TuBridge flow diverters. Interv Neuroradiol. 2020;26(5):539-46. https://doi. org/10.1177/1591019920946216. PMid:32722987.

4. Brzegowy P, Polak J, Wnuk J, et al. Endovascular treatment of middle cerebral artery aneurysms – single-centre results. Pol J Radiol. 2020;85(1): 650-6. https://doi.org/10.5114/pjr.2020.103204. PMid:33552317.

5. Zaidat OO, Castonguay AC, Teleb MS, et al. Middle cerebral artery aneurysm endovascular and surgical therapies: comprehensive literature review and local experience. Neurosurgery Clinics. 2014;25(3):455-69. PMid:24994084.

6. Cunha CEG, Correia CC. Middle cerebral artery extension and the risk for aneurysmal disease. J Neurol Sci. 2018;390:219-21. https://doi. org/10.1016/j.jns.2018.04.040. PMid:29801892.

7. Kaspera W, Ćmiel-Smorzyk K, Wolański W, et al. Morphological and hemodynamic risk factors for middle cerebral artery aneurysm: a case-control study of 190 patients. Sci Rep. 2020;10(1):2016. https://doi.org/10.1038/s41598-019-56061-2. PMid:32029748.

8. Santiago-Dieppa DR, Pannell JS, Khalessi AA. Endovascular and surgical options for ruptured middle cerebral artery aneurysms: review of the literature. Stroke Res Treat. 2014;2014(1):315906. https://doi. org/10.1155/2014/315906. PMid:25097795.

9. Brisman JL, Song JK, Newell DW. Cerebral aneurysms. N Engl J Med. 2006;355(9):928-39. https://doi.org/10.1056/NEJMra052760. PMid:16943405.

10. Ikawa F, Abiko M, Ishii D, et al. Effect of actual age on outcome at discharge in patients by surgical clipping and endovascular coiling for ruptured cerebral aneurysm in Japan. Neurosurg Rev. 2018;41(4): 1007-11. https://doi.org/10.1007/s10143-017-0942-9. PMid:29335886.

11. Wiebers DO, Whisnant JP, Huston J 3rd, et al. Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment. Lancet. 2003;362(9378):103-10. https://doi. org/10.1016/S0140-6736(03)13860-3. PMid:12867109.

12. Lawton MT, Vates GE. Subarachnoid Hemorrhage. N Engl J Med. 2017;377(3):257-66. https://doi.org/10.1056/NEJMcp1605827. PMid:28723321.

13. Brown RD Jr, Broderick JP. Unruptured intracranial aneurysms: epidemiology, natural history, management options, and familial screening. Lancet Neurol. 2014;13(4):393-404. https://doi.org/10.1016/ S1474-4422(14)70015-8. PMid:24646873.

14. Stefani MA, Schneider FL, Marrone ACH, Severino AG. Influence of the gender on cerebral vascular diameters observed during the magnetic resonance angiographic examination of willis circle. Braz Arch Biol Technol. 2013;56(1):45-52. https://doi.org/10.1590/S1516-89132013000100006.

15. Galvao J, Lima DD, Haas LJ. Prevalência de aneurismas cerebrais incidentais entre homens e mulheres. Saude Pesqui. 2020;13(2):309-16. https://doi.org/10.17765/2176-9206.2020v13n2p309-316.

16. Nielsen R, Hauerberg J, Munthe S, et al. Screening for intracranial aneurysms. Ugeskr Læger. 2019;181(2). PMid:30618370.

17. Weir B. Unruptured intracranial aneurysms: a review. J Neurosurg. 2002;96(1):3-42. https://doi.org/10.3171/jns.2002.96.1.0003. PMid:11794601.

18. Lanzino G, Fraser K, Kanaan Y, Wagenbach A. Treatment of ruptured intracranial aneurysms since the International Subarachnoid Aneurysm Trial: practice utilizing clip ligation and coil embolization as individual or complementary therapies. J Neurosurg. 2006;104(3): 344-9. https://doi.org/10.3171/jns.2006.104.3.344. PMid:16572645.

19. Jiang B, Paff M, Colby GP, Coon AL, Lin LM. Cerebral aneurysm treatment: modern neurovascular techniques. Stroke Vasc Neurol. 2016;1(3):93-100. https://doi.org/10.1136/svn-2016-000027. PMid:28959469.

20. Brinjikji W, Lanzino G, Cloft HJ, Rabinstein A, Kallmes DF. Endovascular treatment of middle cerebral artery aneurysms. Neurosurgery. 2011;68(2): 397-402. https://doi.org/10.1227/NEU.0b013e318201d7f4. PMid:21135730.

21. Gao F, Guo X, Han J, Sun X, Zhou Z, Miao Z. Endovascular recanalization for symptomatic non-acute middle cerebral artery occlusion: proposal of a new angiographic classification. J Neurointerv Surg. 2021;13(10):900-5. https://doi.org/10.1136/neurintsurg-2020-016692. PMid:33122350.

22. Sumi T, Kawamoto S, Fukaya S, Ueki K, Kim P. Middle cerebral artery aneurysm associated with moyamoya disease. World Neurosurg. 2020;140:233-6. https://doi.org/10.1016/j.wneu.2020.05.111. 

PMid:32434024.



2Fundação Universidade Regional de Blumenau (FURB), Blumenau - Santa Catarina, Brazil

3Universidade Regional de Blumenau (Medicine), Blumenau - Santa Catarina, Brazil

 

2Fundação Universidade Regional de Blumenau (FURB), Blumenau - Santa Catarina, Brazil

3Universidade Regional de Blumenau (Medicine), Blumenau - Santa Catarina, Brazil


JBNC  Brazilian Journal of Neurosurgery

JBNC
  •   ISSN (print version): 0103-5118
  •   e-ISSN (online version): 2446-6786
iThenticate
Open Access

Contact

Social Media

   

ABNc  Academia Brasileira de Neurocirurgia

  •   Rua da Quitanda 159 – 10º andar - Centro - CEP 20091-005 - Rio de Janeiro - RJ
  •   +55 21 2233.0323
  •    abnc@abnc.org.br

Sponsor

  • Hospital INC