REVIEW
Introdução: A angina cervical é uma síndrome rara caracterizada por dor torácica não cardíaca, frequentemente confundida com angina pectoris. Sua origem está associada a patologias cervicais, como espondilose e radiculopatia, representando um desafio diagnóstico relevante na prática clínica. Objetivo: Analisar os aspectos clínicos, complicações e condutas terapêuticas da angina cervical por meio de uma revisão integrativa da literatura. Métodos: Foi realizada uma revisão integrativa utilizando as bases de dados PubMed e CAPES Periódicos. Foram incluídos estudos publicados nos últimos dez anos, em português ou inglês, disponíveis na íntegra. Excluíram-se revisões sistemáticas, capítulos de livros e artigos de revisão. Resultados: A angina cervical manifesta-se como dor torácica anterior, frequentemente acompanhada de sintomas autonômicos como dispneia, vertigem e cefaleia. Os níveis cervicais mais envolvidos são C5-C6 e C6-C7. O diagnóstico exige exclusão de causas cardíacas, exames de imagem e testes clínicos específicos, como a manobra de Spurling. O manejo terapêutico inclui abordagens conservadoras (medicação, fisioterapia, quiropraxia) e intervencionistas (injeções, bloqueios), além de cirurgias como discectomia cervical anterior e artroplastia, indicadas para casos refratários. Conclusão: A angina cervical é uma condição subdiagnosticada que demanda atenção multidisciplinar. O reconhecimento precoce, aliado a uma abordagem terapêutica individualizada, pode reduzir morbidades e melhorar significativamente a qualidade de vida dos pacientes.
Introduction: Cervical angina is a rare syndrome characterized by non-cardiac chest pain, often mistaken for angina pectoris. It originates from cervical spine pathologies such as spondylosis and radiculopathy, representing a significant diagnostic challenge in clinical practice. Objective: To analyze the clinical aspects, complications, and therapeutic approaches of cervical angina through an integrative literature review. Methods: An integrative review was conducted using the PubMed and CAPES Periódicos databases. Studies published within the last ten years, in Portuguese or English, and available in full text were included. Systematic reviews, book chapters, and review articles were excluded. Results: Cervical angina presents as anterior chest pain, frequently associated with autonomic symptoms such as dyspnea, vertigo, and headache. The most commonly affected cervical levels are C5-C6 and C6-C7. Diagnosis requires the exclusion of cardiac causes, imaging exams, and specific clinical tests such as Spurling’s maneuver. Therapeutic management includes conservative strategies (medication, physiotherapy, chiropractic care) and interventional procedures (injections, nerve blocks), as well as surgical interventions like anterior cervical discectomy and fusion or disc arthroplasty in refractory cases. Conclusion: Cervical angina remains an underdiagnosed condition requiring multidisciplinary awareness. Early recognition, combined with individualized therapeutic planning, can reduce patient morbidity and significantly improve quality of life.
1. Feng F, Chen X, Shen H. Cervical angina: a literature review on its diagnosis, mechanism, and management. Asian Spine J. 2021;15(4):5506. http://doi.org/10.31616/asj.2020.0269. PMid:33108845.
2. Chu EC-P. Cervical radiculopathy as a hidden cause of angina: cervicogenic angina. J Med Cases. 2022;13(11):545-50. http:// doi.org/10.14740/jmc4025. PMid:36506762.
3. Chu EC-P, Yun S, Huang KHK. Cervicogenic angina and dyspnea secondary to cervical radiculopathy. Cureus. 2023;15(4):e37515. http:// doi.org/10.7759/cureus.37515. PMid:37064724.
4. Phillips J. The importance of examination of the spine in the presence of intrathoracic or abdominal pain. Proc Int Postgrad MA North Am. 1927;70:3.
5. Chien JT, Hsieh MH, Yang CC, Chen IH, Lee RP. Anterior Cervical discectomy and fusion versus conservative treatment for cervical angina conservative treatment. Clin Spine Surg. 2021;34(9):E514-21. http:// doi.org/10.1097/BSD.0000000000001178. PMid:33828047.
6. Nakajima H, Uchida K, Kobayashi S, et al. Cervical angina: a seemingly still neglected symptom of cervical spine disorder? Spinal Cord. 2006;44(8):509-13. http://doi.org/10.1038/sj.sc.3101888. PMid:16331305.
7. Lepor NE, McCullough PA. Differential diagnosis and overlap of acute chest discomfort and dyspnea in the emergency department. Rev Cardiovasc Med. 2010;11(S2, Suppl 2):S13-23. http://doi.org/10.3909/ ricm11S2S0006. PMid:20700098.
8. Bogduk N, Govind J. Cervicogenic headache: an assessment of the evidence on clinical diagnosis, invasive tests, and treatment. Lancet Neurol. 2009;8(10):959-68. http://doi.org/10.1016/S1474-4422(09)70209-1.
PMid:19747657.
9. Higashimoto Y, Sano A, Nishiyama O, et al. Prefrontal cortex activation is associated with dyspnea during methacholine bronchial provocation tests in patients with bronchial asthma. Allergol Int. 2020;69(3):453-4. http://doi.org/10.1016/j.alit.2019.12.005. PMid:32113986.
10. Chu EC-P, Wong AY-L. Cervicogenic dizziness in an 11-year-old girl: a case report. Adolesc Health Med Ther. 2021;12:111-6. http:// doi.org/10.2147/AHMT.S341069. PMid:34866956.
11. Bryans R, Descarreaux M, Duranleau M, et al. EvidenceBased guidelines for the chiropractic treatment of adults with headache. J Manipulative Physiol Ther. 2011;34(5):274-89. http:// doi.org/10.1016/j.jmpt.2011.04.008. PMid:21640251.
12. Passmore SR, Dunn AS. Positive patient outcome after spinal manipulation in a case of cervical angina. Man Ther. 2009;14(6):702-5. http://doi.org/10.1016/j.math.2009.03.005. PMid:19380246.
13. Thoomes EJ, Scholten-Peeters GGM, De Boer AJ, et al. Lack of uniform diagnostic criteria for cervical radiculopathy in conservative intervention studies: a systematic review. Eur Spine J. 2012;21(8):145970. http://doi.org/10.1007/s00586-012-2297-9. PMid:22531897.
14. Abe T, Tanei T, Nishimura Y, Saito R. True angina pectoris immediately after cervical disc herniation surgery for preoperative cervical angina symptoms: a case report. Cureus. 2022;14(8):e28313. http://doi.org/10.7759/cureus.28313. PMid:36168361.
15. Sussman WI, Makovitch SA, Merchant SHI, Phadke J. Cervical angina: an overlooked source of noncardiac chest pain. Neurohospitalist. 2015;5(1):227. http://doi.org/10.1177/1941874414550558. PMid:25553225.
16. Brodsky AE. Cervical angina: a correlational study with emphasis on the use of coronary arteriography. Spine. 1985;10(8):699-709. http:// doi.org/10.1097/00007632-198510000-00003. PMid:4081876.
17. LaBan MM, Meerschaert JR, Taylor RS. Breast pain: a symptom of cervical radiculopathy. Arch Phys Med Rehabil. 1979;60(7):315-7. PMid:454130.
18. Nakae Y, Johkura K, Kudo Y, Kuroiwa Y. Spinal cord infarction with cervical angina. J Neurol Sci. 2013;324(1-2):195-6. http:// doi.org/10.1016/j.jns.2012.11.005. PMid:23199591.
19. Kültür Y, Bal E. Intermediate to long-term clinical and radiological results of cervical disc prosthesis: a comparative study with anterior cervical discectomy and fusion. Jtss. 2025;36(2):71-6. http:// doi.org/10.4274/jtss.galenos.2025.59251.
20. Youssef EM, Abdeen M, Saleh MK, Eladawy A, Alaa Eldin AM. Outcomes of minimally invasive posterior cervical foraminotomy for unilateral cervical radiculopathy. Advanced Spine Journal. 2025;43(1):310. http://doi.org/10.57055/2974-4822.1314.
21. Taso M, Sommernes JH, Sundseth J, et al. Surgical versus nonsurgical treatment for cervical radiculopathy. NEJM Evidence. 2025;4(4):a2400404. http://doi.org/10.1056/EVIDoa2400404.
PMid:40130970.
22. Schultz DM, Hagedorn JM, Abd-Elsayed A, Stayner S. Safety of interlaminar cervical epidural injections: experience with 12,168 procedures in a single pain clinic. Pain Physician. 2022;25(1):49-58. PMid:35051144.
23. Shi C, Xu N, Sun B, et al. Clinical outcomes of posterior percutaneous endoscopic cervical foraminotomy and discectomy assisted with SNRB in treating cervical radiculopathy with diagnostic uncertainty. Pain Physician. 2021;24(4):E483-92. PMid:34213874.
24. Al Jammal OM, Diaz-Aguilar LD, Srinivas S, Plonsker J, Sahyouni R, Pham MH. Cervical arthroplasty in the treatment of cervical angina: case report and review of the literature. Neurospine. 2020;17(4):929-38. http://doi.org/10.14245/ns.2040074.037. PMid:33401872.
25. Htay MNN, Ni H, Moe S. Cervical spondylosis mimicking cardiac angina. J Case Rep Images Med. 2019;5: 100050Z09MH2019.
26. Carlton L, Maccio JR, Handford J, Patel P. The application of mechanical diagnosis and therapy in failed anterior cervical discectomy and fusion: a case report. OROAJ. 2017;9(4). http://doi.org/10.19080/ OROAJ.2017.09.555766.
27. Kato K, Yabuki S, Otani K, et al. Unusual chest wall pain caused by thoracic disc herniation in a professional baseball pitcher. Fukushima J Med Sci. 2016;62(1):64-7. http://doi.org/10.5387/fms.2015-25. PMid:26983590.
28. Ozgur BM, Marshall LF. Atypical presentation of C-7 radiculopathy. J Neurosurg. 2003;99(2, Suppl):169-71. http://doi.org/10.3171/ spi.2003.99.2.0169. PMid:12956459.
29. Jacobs B. Cervical angina. NY State J Med. 1990;90(1):8-11. PMid:2296405.
30. Childress MA, Becker BA. Nonoperative management of cervical radiculopathy. Am Fam Physician. 2016;93(9):746-54. PMid:27175952.
31. Magnus W, Viswanath O, Viswanathan VK, Mesfin FB. Cervical radiculopathy. Treasure Island: StatPearls Publishing; 2025.
32. Cheshire WP Jr. Spinal cord infarction mimicking angina pectoris. Mayo Clin Proc. 2000;75(11):1197-9. http://doi.org/10.4065/75.11.1197. PMid:11075751.
33. Brown NJ, Shahrestani S, Lien BV, et al. Spinal pathologies and management strategies associated with cervical angina (pseudoangina): a systematic review. J Neurosurg Spine. 2021;34(3):506-13. http://doi.org/10.3171/2020.7.SPINE20866. PMid:33276331.
34. Dydyk AM, Hu Y, Stretanski MF, Sekhri NK. Cervical epidural injection. Treasure Island: StatPearls Publishing; 2025.
35. Laratta JL, Reddy HP, Bratcher KR, McGraw KE, Carreon LY, Owens RK 2nd. Outcomes and revision rates following multilevel anterior cervical discectomy and fusion. J Spine Surg. 2018;4(3):496-500. http:// doi.org/10.21037/jss.2018.06.16. PMid:30547110.
1Universidade Federal de Sergipe, Aracaju, SE, Brazil.
2Universidade Federal de Sergipe, Lagarto, SE, Brazil.
Received Jul 22, 2025
Accepted Aug 11, 2025