CASE REPORT
Introdução: Estudo de um caso de tumor invasivo intraparenquimatoso frontal de difícil diagnóstico final, o Glioma Angiocêntrico (GAC). Objetivo: Apresentar um caso raro de difícil diagnóstico, possibilitado através do estudo multidisciplinar, com os dados clínicos, neurorradiológicos, cirúrgicos e anatomopatológicos. Método: Estudo comparativo entre a apresentação do caso, com os achados pela Ressonância Magnética (RM) do Crânio., confrontados com os resultados anatomopatológicos, usando microscopia óptica (MO) bem como imunohistoquímica (IHQ). Resultados: Comparando os achados neurorradiológicos e anatomopatológicos, permitiram o diagnóstico final de GAC. Conclusão: Considerando-se os dados clínicos, neurorradiológicos e anatomopatológicos, valendo-se da literatura consultada, o diagnóstico de um glioma maligno de típico subtipo angiocêntrico se fez possível, com implicações não só classificatórias, como na conduta terapêutica.
Introduction: Study of a case of an invasive intraparenchymal frontal tumor with a difficult final diagnosis, Angiocentric Glioma (ACG). Objective: To present a rare case of difficult diagnosis, made possible through a multidisciplinary study, with clinical, neuroradiological, surgical and anatomopathological data. Method: Comparative study between the case presentation, with the findings of Magnetic Resonance Imaging (MRI) of the Skull, confronted with the anatomopathological results, using light microscopy (OM) as well as immunohistochemistry (IHC). Results: Comparing the neuroradiological and anatomopathological findings allowed the final diagnosis of ACG. Conclusion: Considering the clinical, neuroradiological and anatomopathological data, using the consulted literature, the diagnosis of a malignant glioma of a typical angiocentric subtype was possible, with implications not only for classification, but also for therapeutic conduct.
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1Anatomopathological Service – APS, Hospital Municipal Salgado Filho – HMSF/RJ, Rio de Janeiro, RJ, Brazil.
2Neurosurgery Service – NSS, Hospital Municipal Salgado Filho – HMSF/RJ, Rio de Janeiro, RJ, Brazil.
3School of Medicine, Federal Fluminense University – UFF/RJ, Niteroi, RJ, Brazil.
Received Feb 27, 2026
Corrected Apr 6, 2026
Accepted Jun 11, 2026
